dynorphin

简明释义

英[daɪˈnɔːfɪn]美[daɪˈnɔːrfɪn]

[生化] 强啡肽

力啡肽

英英释义

单词用法

同义词

反义词

例句

1.Objective to study the effect of oxytocin (OT) on pain modulation in spinal cord and its relation to endogenous met-enkephalin and dynorphin A_ (1-13).

目的探讨脊髓内催产素(OT)与内源性脑啡肽和强啡肽a _(1 ~ 13)在痛觉调制中的关系。

2.Objective to study the effect of oxytocin (OT) on pain modulation in spinal cord and its relation to endogenous met-enkephalin and dynorphin A_ (1-13).

目的探讨脊髓内催产素(OT)与内源性脑啡肽和强啡肽a _(1 ~ 13)在痛觉调制中的关系。

3.Researchers found that increased levels of dynorphin can lead to heightened pain sensitivity.

研究人员发现，增加的dynorphin水平可能导致疼痛敏感性增强。

4.Chronic pain conditions may be linked to dysregulation of dynorphin levels in the body.

慢性疼痛状况可能与体内dynorphin水平的失调有关。

5.The role of dynorphin in stress responses has been a topic of significant research.

dynorphin在压力反应中的作用一直是重要研究的主题。

6.In animal studies, blocking dynorphin receptors has shown promise in reducing anxiety-like behaviors.

在动物研究中，阻断dynorphin受体已显示出减少焦虑行为的潜力。

7.The interaction between opioids and dynorphin could explain some of the complexities of pain management.

阿片类药物与dynorphin之间的相互作用可能解释了疼痛管理的一些复杂性。

作文

The human body is a marvel of biological engineering, with numerous systems working in harmony to maintain homeostasis. One of the lesser-known yet fascinating components of our neurochemistry is a peptide known as dynorphin. This endogenous opioid peptide plays a crucial role in modulating pain, stress responses, and emotional regulation. Understanding dynorphin can provide insights into how our bodies cope with pain and stress, and may even lead to new therapeutic approaches for managing chronic pain and mood disorders.Dynorphin is primarily produced in the brain and spinal cord, where it binds to kappa opioid receptors. This binding action has several effects, including the inhibition of pain signals and the modulation of emotional responses. Unlike other opioids that primarily induce feelings of pleasure, dynorphin is often associated with dysphoria, or negative emotional states. This paradoxical effect is particularly interesting because it suggests that dynorphin serves a protective function, preventing overindulgence in pleasurable activities and promoting a balanced emotional state.Research has shown that levels of dynorphin can be influenced by various factors, including stress, addiction, and physical exercise. For instance, during periods of intense stress, the body increases the production of dynorphin, which may help to dampen the overwhelming feelings of anxiety and pain. However, this increase can also contribute to the experience of withdrawal symptoms in individuals recovering from substance abuse, as the body struggles to regain its natural balance without the influence of external opioids.Moreover, the role of dynorphin extends beyond pain management. It has been implicated in various neuropsychiatric disorders, such as depression and schizophrenia. Studies indicate that dysregulation of dynorphin signaling may contribute to the pathophysiology of these conditions, making it a potential target for new treatment strategies. By understanding how dynorphin functions within the brain's reward and stress systems, researchers hope to develop more effective therapies that can alleviate symptoms without the risk of addiction associated with traditional opioid medications.In addition to its implications for mental health, dynorphin also plays a significant role in the body's response to physical activity. Exercise has been shown to elevate levels of dynorphin, which may contribute to the 'runner's high' phenomenon experienced by many athletes. This elevation not only helps to reduce pain during prolonged exertion but also enhances mood, showcasing the complex interplay between physical activity, neurochemistry, and emotional well-being.In conclusion, dynorphin is a multifaceted peptide that plays a critical role in pain modulation, stress response, and emotional regulation. Its unique properties set it apart from other opioid peptides, highlighting its importance in maintaining a balanced state of mind and body. As research continues to uncover the complexities of dynorphin and its interactions within the brain, we can look forward to new insights that may pave the way for innovative treatments for pain, addiction, and mood disorders. Understanding dynorphin not only enhances our knowledge of neurobiology but also emphasizes the intricate connections between our physical and emotional health.

人类身体是生物工程的奇迹，众多系统和谐地协同工作以维持内稳态。我们神经化学中的一个鲜为人知但引人入胜的组成部分是被称为dynorphin的肽。这种内源性阿片肽在调节疼痛、应激反应和情绪调节中发挥着至关重要的作用。理解dynorphin可以提供有关我们身体如何应对疼痛和压力的见解，甚至可能导致新的治疗方法来管理慢性疼痛和情绪障碍。Dynorphin主要在大脑和脊髓中产生，它与κ-阿片受体结合。这种结合作用具有多种效果，包括抑制疼痛信号和调节情绪反应。与其他主要引起愉悦感的阿片类药物不同，dynorphin通常与不快或负面情绪状态相关联。这种矛盾效应尤其有趣，因为它表明dynorphin具有保护功能，防止过度沉迷于愉悦活动并促进情绪状态的平衡。研究表明，dynorphin的水平会受到多种因素的影响，包括压力、成瘾和体育锻炼。例如，在剧烈压力期间，身体会增加dynorphin的产生，这可能有助于减轻焦虑和疼痛的压倒性感觉。然而，这种增加也可能导致戒断症状的出现，尤其是在从药物滥用中恢复的个体中，因为身体在没有外部阿片类药物的影响下努力恢复自然平衡。此外，dynorphin的作用超出了疼痛管理。它已被涉及各种神经精神疾病，如抑郁症和精神分裂症。研究表明，dynorphin信号的不调节可能会导致这些疾病的病理生理，使其成为新的治疗策略的潜在目标。通过了解dynorphin在大脑奖赏和压力系统中的功能，研究人员希望开发出更有效的疗法，能够缓解症状而不带来传统阿片类药物相关的成瘾风险。除了对心理健康的影响，dynorphin还在身体对体育活动的反应中发挥着重要作用。研究表明，锻炼可以提高dynorphin的水平，这可能有助于许多运动员所经历的“跑者高潮”现象。这种升高不仅有助于在长时间的运动过程中减少疼痛，还能改善心情，展示了身体活动、神经化学和情绪健康之间复杂的相互作用。总之，dynorphin是一种多面性的肽，在疼痛调节、应激反应和情绪调节中发挥着关键作用。它独特的特性使其与其他阿片肽区分开来，突显了它在维持身心平衡状态中的重要性。随着研究不断揭示dynorphin及其在大脑中的相互作用的复杂性，我们可以期待新的见解，这些见解可能为疼痛、成瘾和情绪障碍的创新治疗铺平道路。理解dynorphin不仅增强了我们对神经生物学的知识，也强调了我们身体和情绪健康之间的复杂联系。