base deletion

简明释义

碱基缺失

英英释义

例句

1.The patient’s condition was linked to a specific base deletion in the BRCA1 gene.

患者的病情与BRCA1基因中的特定碱基缺失有关。

2.The geneticist explained that the mutation was caused by a base deletion in the DNA sequence.

遗传学家解释说，这种突变是由于DNA序列中的碱基缺失造成的。

3.Researchers are studying the impact of base deletion on gene expression in various organisms.

研究人员正在研究碱基缺失对各种生物体基因表达的影响。

4.A base deletion can lead to frameshift mutations, altering the entire reading frame of a gene.

一个碱基缺失可能导致移码突变，改变基因的整个阅读框。

5.During the experiment, we observed a significant effect of base deletion on protein synthesis.

在实验过程中，我们观察到碱基缺失对蛋白质合成有显著影响。

作文

In the field of genetics, the term base deletion refers to a type of mutation where one or more nucleotide bases are removed from a DNA sequence. This alteration can have significant effects on the organism, potentially leading to various genetic disorders or diseases. Understanding base deletion is crucial for researchers and medical professionals as it helps in diagnosing and treating genetic conditions. To illustrate the importance of base deletion, consider the example of cystic fibrosis, a genetic disorder caused by mutations in the CFTR gene. One common mutation associated with this disease is a base deletion of three nucleotides, which leads to the loss of a single amino acid in the protein produced by this gene. This seemingly small change can disrupt the normal function of the CFTR protein, resulting in the severe respiratory and digestive problems characteristic of cystic fibrosis.Moreover, base deletion can lead to frameshift mutations, which occur when the deletion shifts the reading frame of the genetic code. This can result in the production of an entirely different protein, often leading to nonfunctional or harmful outcomes. For instance, if a gene that normally codes for an enzyme necessary for metabolism undergoes a base deletion, the resulting protein may not be able to perform its intended function, potentially leading to metabolic disorders.The study of base deletion is not limited to human health; it also has implications in agriculture and biotechnology. Scientists can use techniques like CRISPR-Cas9 to deliberately induce base deletion in plant genomes to create crops that are more resistant to diseases or environmental stressors. By understanding how base deletion affects gene function, researchers can develop innovative solutions to enhance food security and sustainability.In conclusion, base deletion is a critical concept in genetics that encompasses a range of implications for health, disease, and biotechnology. By exploring the mechanisms and consequences of base deletion, we can gain valuable insights into the complexities of genetic information and its impact on living organisms. As research continues to advance, the knowledge surrounding base deletion will undoubtedly play a key role in shaping future medical and agricultural practices.

在遗传学领域，术语碱基缺失指的是一种突变类型，其中一个或多个核苷酸碱基从DNA序列中被移除。这种改变可能对生物体产生重大影响，潜在地导致各种遗传疾病或疾病。理解碱基缺失对研究人员和医疗专业人员至关重要，因为它有助于诊断和治疗遗传病。 为了说明碱基缺失的重要性，考虑囊性纤维化的例子，这是一种由CFTR基因中的突变引起的遗传疾病。与这种疾病相关的一种常见突变是三个核苷酸的碱基缺失，这导致该基因产生的蛋白质中缺少一个氨基酸。这种看似微小的变化可以破坏CFTR蛋白的正常功能，导致囊性纤维化特有的严重呼吸和消化问题。 此外，碱基缺失可能导致框移突变，当缺失改变遗传密码的阅读框时就会发生这种情况。这可能导致产生完全不同的蛋白质，通常会导致无功能或有害的结果。例如，如果一个正常编码代谢所需酶的基因发生碱基缺失，则产生的蛋白质可能无法执行其预期功能，从而可能导致代谢障碍。 对碱基缺失的研究不仅限于人类健康；它还在农业和生物技术中具有重要意义。科学家可以使用CRISPR-Cas9等技术故意在植物基因组中诱导碱基缺失，以创造出更能抵抗疾病或环境压力的作物。通过了解碱基缺失如何影响基因功能，研究人员可以开发创新解决方案，以增强粮食安全和可持续性。 总之，碱基缺失是遗传学中的一个关键概念，涵盖了对健康、疾病和生物技术的一系列影响。通过探索碱基缺失的机制和后果，我们可以获得关于遗传信息复杂性及其对生物体影响的宝贵见解。随着研究的不断进展，围绕碱基缺失的知识无疑将在塑造未来医学和农业实践中发挥关键作用。