antagonistic inhibition

简明释义

对抗抑制

英英释义

例句

1.The phenomenon of antagonistic inhibition 拮抗性抑制 is crucial for understanding complex biological systems.

理解复杂生物系统时，antagonistic inhibition 拮抗性抑制现象至关重要。

2.Their findings suggested that antagonistic inhibition 拮抗性抑制 could be a key factor in the resistance observed in some patients.

他们的发现表明，antagonistic inhibition 拮抗性抑制可能是一些患者观察到的耐药性的关键因素。

3.The researchers measured the level of antagonistic inhibition 拮抗性抑制 in various cell lines to evaluate drug interactions.

研究人员测量了不同细胞系中的antagonistic inhibition 拮抗性抑制水平，以评估药物相互作用。

4.The study revealed that the drug exhibited antagonistic inhibition 拮抗性抑制 of the receptor, which could lead to reduced efficacy.

研究显示该药物表现出对受体的antagonistic inhibition 拮抗性抑制，这可能导致疗效降低。

5.In cancer therapy, understanding antagonistic inhibition 拮抗性抑制 mechanisms can help in designing more effective treatments.

在癌症治疗中，理解antagonistic inhibition 拮抗性抑制机制可以帮助设计更有效的治疗方案。

作文

In the field of neuroscience and pharmacology, understanding the mechanisms of how different substances interact with the nervous system is crucial. One of the concepts that arise in this context is antagonistic inhibition, which refers to a process where one substance or signal counteracts the effects of another. This phenomenon can be observed in various biological systems and has significant implications for drug development and therapeutic interventions.To explore the concept of antagonistic inhibition, let us consider its application in neurotransmission. Neurotransmitters are chemicals that transmit signals across synapses from one neuron to another. Some neurotransmitters can have excitatory effects, promoting the firing of neurons, while others have inhibitory effects, suppressing neuronal activity. In some cases, an excitatory neurotransmitter may be counteracted by an inhibitory neurotransmitter, leading to a balanced response in the nervous system. This balance is essential for maintaining homeostasis and ensuring proper functioning of the brain and body.For instance, consider the neurotransmitter glutamate, which is primarily excitatory, and gamma-aminobutyric acid (GABA), which is inhibitory. When glutamate binds to its receptors, it leads to increased neuronal firing. However, if GABA is simultaneously activated, it can inhibit the excitatory effects of glutamate through antagonistic inhibition. This interaction illustrates how opposing forces within the nervous system can regulate neuronal activity, preventing over-excitation that could lead to conditions such as seizures or anxiety disorders.Furthermore, the principle of antagonistic inhibition extends beyond neurotransmission. In pharmacology, drugs can act as antagonists to block the action of certain receptors or neurotransmitters. For example, opioid antagonists like naloxone work by inhibiting the effects of opioids on their receptors, effectively reversing opioid overdose. Understanding how these antagonistic interactions work is vital for developing effective treatments for various medical conditions.Moreover, the study of antagonistic inhibition is not limited to the nervous system; it also plays a role in other biological systems, such as the endocrine system. Hormones often interact in complex ways, where one hormone may enhance the effect of another while another may inhibit it. For example, insulin and glucagon have opposing effects on blood glucose levels, with insulin lowering glucose levels and glucagon raising them. The balance between these hormones is crucial for metabolic homeostasis, showcasing another aspect of antagonistic inhibition in the human body.In conclusion, antagonistic inhibition is a fundamental concept that helps explain how various biological systems maintain balance and function effectively. Whether in the context of neurotransmission, pharmacology, or hormonal regulation, understanding this phenomenon is essential for advancing our knowledge of health and disease. As research continues to uncover the complexities of these interactions, we can better develop targeted therapies that harness the power of antagonistic inhibition to improve patient outcomes and enhance our understanding of human physiology.

在神经科学和药理学领域，理解不同物质如何与神经系统相互作用的机制至关重要。在这个背景下，一个出现的概念是拮抗抑制，它指的是一种过程，其中一种物质或信号抵消另一种物质的效果。这种现象可以在各种生物系统中观察到，并对药物开发和治疗干预具有重要意义。为了探讨拮抗抑制的概念，让我们考虑它在神经传递中的应用。神经递质是通过突触从一个神经元传递信号到另一个神经元的化学物质。一些神经递质可能具有兴奋性效果，促进神经元的放电，而另一些则具有抑制性效果，抑制神经活动。在某些情况下，兴奋性神经递质可能会被抑制性神经递质抵消，从而导致神经系统的平衡反应。这种平衡对于维持稳态和确保大脑及身体的正常功能至关重要。例如，考虑主要兴奋性的神经递质谷氨酸和抑制性的γ-氨基丁酸（GABA）。当谷氨酸与其受体结合时，会导致神经元放电增加。然而，如果GABA同时被激活，它可以通过拮抗抑制来抑制谷氨酸的兴奋性效果。这种相互作用说明了神经系统内对立力量如何调节神经活动，防止过度兴奋，这可能导致癫痫或焦虑症等疾病。此外，拮抗抑制的原理不仅限于神经传递。在药理学中，药物可以作为拮抗剂来阻断某些受体或神经递质的作用。例如，阿片类拮抗剂如纳洛酮通过抑制阿片类药物对其受体的作用，有效逆转阿片类药物过量。理解这些拮抗相互作用的工作原理对于开发各种医疗条件的有效治疗方案至关重要。此外，拮抗抑制的研究不仅限于神经系统；它在内分泌系统等其他生物系统中也发挥着作用。激素往往以复杂的方式相互作用，其中一种激素可能增强另一种激素的效果，而另一种则可能抑制它。例如，胰岛素和胰高血糖素在血糖水平上具有相反的效果，胰岛素降低血糖水平，而胰高血糖素提高它们。这些激素之间的平衡对代谢稳态至关重要，展示了人类身体中拮抗抑制的另一个方面。总之，拮抗抑制是一个基本概念，有助于解释各种生物系统如何保持平衡并有效运作。无论是在神经传递、药理学还是激素调节的背景下，理解这一现象对于推动我们对健康和疾病的理解至关重要。随着研究不断揭示这些相互作用的复杂性，我们可以更好地开发针对性的治疗方法，利用拮抗抑制的力量来改善患者的结果，并增强我们对人体生理的理解。