methylating

简明释义

英[ˈmɛθəˌleɪtɪŋ]美[ˈmɛθəˌleɪtɪŋ]

v. 使甲基化（methylate 的现在分词）

英英释义

单词用法

同义词

反义词

例句

1.Sulfuric acid dimethyl ester, one of the important chemical raw materials ACTS as the methylating agent in the organic synthesis for the purpose of replacing alkyl halide.

硫酸二甲酯是一种重要的化工原料，在有机合成中用于代替卤代烷作为甲基化剂。

2.A byproduct in the methylating reaction was separated, purified and determined to be of the dimethylated product for the first time.

首次分离、纯化了甲基化反应的重要副产物，经元素分析、氢谱、质谱确定为双甲基化产物。

3.Sulfuric acid dimethyl ester, one of the important chemical raw materials ACTS as the methylating agent in the organic synthesis for the purpose of replacing alkyl halide.

硫酸二甲酯是一种重要的化工原料，在有机合成中用于代替卤代烷作为甲基化剂。

4.Finally, methylating agent attacks sulfide in assemblage to cleavage carbon - sulfur bond.

最后，甲基化试剂再进攻集合物中的硫醚，从而导致碳硫键的断裂。

5.The methylating process can be influenced by environmental factors.

环境因素可以影响甲基化过程。

6.Certain enzymes are responsible for methylating specific sites on the genome.

某些酶负责在基因组上的特定位点进行甲基化。

7.The process of methylating DNA can affect gene expression.

对DNA进行甲基化的过程可以影响基因表达。

8.Researchers are studying how methylating agents influence cancer development.

研究人员正在研究甲基化剂如何影响癌症的发展。

9.Scientists have identified several compounds that act as methylating'>甲基化剂。

作文

Methylation is a biological process that involves the addition of a methyl group to DNA, proteins, or other molecules. This process, referred to as methylating, plays a crucial role in regulating gene expression, maintaining genomic stability, and influencing various cellular functions. In recent years, scientists have increasingly focused on the implications of methylating processes in health and disease. One of the most significant aspects of methylating is its role in epigenetics, which is the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. When certain genes are methylated, their expression can be silenced, meaning that they are not transcribed into RNA and subsequently translated into proteins. This mechanism is essential for normal development and differentiation of cells. For instance, during embryonic development, specific genes must be turned on or off at precise times, and methylation helps regulate this process. Moreover, the process of methylating is not only limited to genes but also extends to regulatory regions of DNA. These regions, known as promoters, play a vital role in initiating transcription. When a promoter region is heavily methylated, it can prevent the binding of transcription factors, effectively shutting down the expression of associated genes. This dynamic regulation has profound implications for cellular identity and function. In the context of human health, abnormal patterns of methylating have been linked to various diseases, including cancer. Tumor cells often exhibit altered DNA methylation profiles, where tumor suppressor genes may become hypermethylated, leading to their silencing. This loss of function allows for uncontrolled cell growth and division, characteristic of cancer. Conversely, oncogenes, which promote cell proliferation, may become hypomethylated, leading to their overexpression. Understanding these alterations in methylating patterns can provide valuable insights into cancer biology and potential therapeutic targets. Additionally, environmental factors such as diet, pollution, and lifestyle choices can influence the methylating process. For example, nutrients like folate, vitamin B12, and methionine are critical for the synthesis of S-adenosylmethionine (SAMe), a universal methyl donor in biological systems. A deficiency in these nutrients can lead to aberrant methylation patterns, potentially contributing to disease susceptibility. In conclusion, the process of methylating is a fundamental biological mechanism that affects gene expression and cellular function. Its implications extend from normal development to the pathogenesis of diseases such as cancer. As research continues to uncover the complexities of methylation and its regulatory networks, it holds promise for advancing our understanding of biology and developing novel therapeutic strategies. By comprehensively studying methylation, we can unlock new avenues for improving human health and combating diseases.

甲基化是一个生物过程，涉及将甲基基团添加到DNA、蛋白质或其他分子。这个过程被称为甲基化，在调节基因表达、维持基因组稳定性以及影响各种细胞功能方面起着至关重要的作用。近年来，科学家们越来越关注甲基化过程在健康和疾病中的影响。甲基化的一个重要方面是它在表观遗传学中的作用，表观遗传学研究遗传变化在不改变基础DNA序列的情况下的基因表达。当某些基因被甲基化时，它们的表达会被沉默，这意味着它们不会转录为RNA，随后也不会翻译成蛋白质。这种机制对于正常的发展和细胞的分化至关重要。例如，在胚胎发育过程中，特定基因必须在精确的时间被开启或关闭，而甲基化有助于调节这一过程。此外，甲基化过程不仅限于基因，还扩展到DNA的调控区域。这些区域被称为启动子，在启动转录中起着至关重要的作用。当启动子区域被大量甲基化时，它可以阻止转录因子的结合，从而有效地关闭相关基因的表达。这种动态调节对细胞的身份和功能具有深远的影响。在人体健康的背景下，异常的甲基化模式与各种疾病，包括癌症有关。肿瘤细胞通常表现出改变的DNA甲基化谱，其中肿瘤抑制基因可能变得过度甲基化，导致其沉默。这种功能丧失允许细胞不受控制地生长和分裂，这是癌症的特征。相反，促进细胞增殖的癌基因可能变得低甲基化，导致其过度表达。理解这些甲基化模式的改变可以为癌症生物学和潜在的治疗靶点提供有价值的见解。此外，饮食、污染和生活方式等环境因素可以影响甲基化过程。例如，叶酸、维生素B12和蛋氨酸等营养素对于S-腺苷甲硫氨酸（SAMe）的合成至关重要，SAMe是生物系统中的一种普遍甲基供体。这些营养素的缺乏可能导致异常的甲基化模式，可能会导致疾病易感性。总之，甲基化过程是一个基本的生物机制，影响基因表达和细胞功能。它的影响从正常发育到癌症等疾病的发病机制。随着研究继续揭示甲基化及其调控网络的复杂性，它有望推动我们对生物学的理解并开发新型治疗策略。通过全面研究甲基化，我们可以开启改善人类健康和抗击疾病的新途径。