dissociation constant

简明释义

分离常数

英英释义

例句

1.Understanding the dissociation constant helps in predicting the behavior of ionic compounds in solution.

理解 解离常数 有助于预测离子化合物在溶液中的行为。

2.Researchers calculated the dissociation constant for the enzyme-substrate complex to optimize the reaction conditions.

研究人员计算了酶-底物复合物的 解离常数 以优化反应条件。

3.The dissociation constant is crucial for understanding the binding affinity of a drug to its target protein.

解离常数 对于理解药物与其靶蛋白的结合亲和力至关重要。

4.In biochemistry, a lower dissociation constant indicates a stronger interaction between molecules.

在生物化学中，较低的 解离常数 表示分子之间的相互作用更强。

5.The dissociation constant can vary significantly depending on the pH of the solution.

解离常数 会根据溶液的pH值显著变化。

作文

In the field of chemistry, one of the fundamental concepts that scientists must grasp is the concept of the dissociation constant. The dissociation constant (often represented as Kd) is a quantitative measure of the tendency of a complex to dissociate into its components. This concept is particularly important in understanding chemical reactions, especially those involving acids and bases, as well as in biochemistry for enzyme-substrate interactions and ligand-receptor binding. To delve deeper into this concept, let us consider a simple acid-base reaction. When an acid donates a proton (H+) to water, it forms its conjugate base. The equilibrium established between the acid and its conjugate base can be described by the dissociation constant. For instance, when hydrochloric acid (HCl) dissociates in water, we can write the equilibrium expression based on the concentrations of the products and reactants. The dissociation constant helps us understand how strong or weak an acid is; a larger dissociation constant indicates a stronger acid that dissociates more completely in solution.In biochemistry, the dissociation constant plays a crucial role in understanding how enzymes interact with substrates. Enzymes are biological catalysts that speed up chemical reactions, and they do so by binding to specific substrates. The strength of this interaction can be quantified using the dissociation constant. A low dissociation constant implies a strong binding affinity between the enzyme and the substrate, which is essential for effective catalysis. Conversely, a high dissociation constant suggests weaker interactions, which may lead to less efficient enzyme activity.Moreover, the dissociation constant is not just a static number; it can change under different conditions such as pH, temperature, and ionic strength. Understanding these variations is vital for chemists and biochemists alike, as they can significantly impact reaction rates and mechanisms. For example, in physiological conditions, the binding of oxygen to hemoglobin is influenced by the dissociation constant of the hemoglobin-oxygen complex. Changes in pH or carbon dioxide levels can alter the dissociation constant, affecting oxygen delivery to tissues.In conclusion, the dissociation constant is a key parameter in both chemistry and biochemistry, providing insights into the strength of interactions between molecules. Whether it is in the context of acid-base chemistry or biological systems, understanding the implications of the dissociation constant allows scientists to predict the behavior of substances in various environments. As research progresses and new compounds are discovered, the importance of accurately measuring and interpreting the dissociation constant will continue to grow, making it an indispensable tool in the scientific community.

在化学领域，科学家必须掌握的基本概念之一是dissociation constant（解离常数）的概念。dissociation constant（通常表示为Kd）是一个定量测量，用于表征一个复合物解离成其组成部分的倾向。这个概念在理解化学反应时尤为重要，尤其是涉及酸和碱的反应，以及在生物化学中用于酶-底物相互作用和配体-受体结合。为了更深入地理解这一概念，我们可以考虑一个简单的酸碱反应。当酸将质子（H+）捐赠给水时，它形成了其共轭碱。酸与其共轭碱之间建立的平衡可以用dissociation constant来描述。例如，当盐酸（HCl）在水中解离时，我们可以根据产物和反应物的浓度写出平衡表达式。dissociation constant帮助我们理解酸的强弱；较大的dissociation constant表示一种强酸，在溶液中更完全地解离。在生物化学中，dissociation constant在理解酶与底物的相互作用方面发挥着至关重要的作用。酶是加速化学反应的生物催化剂，它们通过与特定底物结合来实现这一点。这种相互作用的强度可以用dissociation constant进行量化。低的dissociation constant意味着酶与底物之间的结合亲和力较强，这对有效催化至关重要。相反，高的dissociation constant则表明相对较弱的相互作用，这可能导致酶活性降低。此外，dissociation constant不仅是一个静态数字；它可以在不同条件下发生变化，例如pH、温度和离子强度。理解这些变化对化学家和生物化学家来说至关重要，因为它们会显著影响反应速率和机制。例如，在生理条件下，氧气与血红蛋白的结合受到血红蛋白-氧气复合物的dissociation constant的影响。pH或二氧化碳水平的变化会改变dissociation constant，从而影响氧气向组织的输送。总之，dissociation constant是化学和生物化学中的一个关键参数，为分子间相互作用的强度提供了见解。无论是在酸碱化学的背景下还是在生物系统中，理解dissociation constant的含义使科学家能够预测物质在各种环境中的行为。随着研究的进展和新化合物的发现，准确测量和解释dissociation constant的重要性将继续增长，使其成为科学界不可或缺的工具。