coiled coil

简明释义

叠螺旋

英英释义

例句

1.The coiled coil configuration is essential in many biological structures like muscle fibers.

在许多生物结构中，如肌肉纤维，卷曲的线圈配置是至关重要的。

2.The engineer designed a new spring using a coiled coil to enhance its elasticity.

工程师设计了一种新的弹簧，使用了卷曲的线圈以增强其弹性。

3.To improve thermal conductivity, the engineers incorporated a coiled coil design in the heat exchanger.

为了提高热导率，工程师在热交换器中采用了卷曲的线圈设计。

4.In the lab, we observed that the coiled coil structure can stabilize proteins during experiments.

在实验室，我们观察到卷曲的线圈结构可以在实验中稳定蛋白质。

5.The artist used a coiled coil technique to create intricate patterns in her sculpture.

艺术家使用卷曲的线圈技术在她的雕塑中创造复杂的图案。

作文

In the fascinating world of molecular biology, the term coiled coil refers to a structural motif in proteins that is characterized by two or more alpha-helices winding around each other. This unique configuration plays a crucial role in various biological processes, including protein-protein interactions, cellular signaling, and the formation of complex structures within cells. Understanding the coiled coil structure is essential for researchers who aim to decipher the intricate mechanisms of life at the molecular level.The significance of the coiled coil motif cannot be overstated. It serves as a fundamental building block for many proteins, contributing to their stability and functionality. For instance, many transcription factors—proteins that help regulate gene expression—contain coiled coils that allow them to dimerize or oligomerize, thereby enhancing their ability to bind DNA and promote transcription. This illustrates how the structural features of proteins can directly influence their biological roles.Moreover, the coiled coil structure is not limited to transcription factors. It is also found in structural proteins such as keratins, which are essential components of hair, nails, and the outer layer of skin. The coiled coil arrangement in keratin provides the necessary strength and resilience, enabling these tissues to withstand mechanical stress. Thus, the study of coiled coils extends beyond simple protein interactions; it encompasses a wide array of biological functions critical for organismal health and development.In addition to their biological importance, coiled coils have garnered interest in the field of biotechnology and materials science. Researchers are exploring the potential of designing synthetic proteins that incorporate coiled coil motifs for various applications, such as drug delivery systems, biomaterials, and nanotechnology. By manipulating the properties of coiled coils, scientists hope to create innovative solutions to address challenges in medicine and engineering.Furthermore, the study of coiled coils has led to significant advancements in our understanding of diseases. Abnormalities in protein folding and interactions involving coiled coils have been implicated in various disorders, including neurodegenerative diseases and cancer. Understanding how these structures function normally can provide insights into how their dysfunction contributes to disease, paving the way for new therapeutic strategies.In conclusion, the coiled coil motif is a remarkable example of nature's ingenuity in protein design. Its versatility and functionality make it a focal point of research in molecular biology, biotechnology, and medicine. As we continue to unravel the complexities of coiled coils, we gain deeper insights into the molecular foundations of life and open new avenues for scientific innovation. The exploration of coiled coils not only enhances our understanding of biology but also holds promise for practical applications that could revolutionize healthcare and technology.

在分子生物学的迷人世界中，术语coiled coil指的是一种蛋白质结构基元，其特征是两个或多个α-螺旋相互缠绕。这种独特的构型在各种生物过程中发挥着至关重要的作用，包括蛋白质-蛋白质相互作用、细胞信号传导和细胞内复杂结构的形成。理解coiled coil结构对于希望解读生命分子机制的研究人员至关重要。coiled coil基元的重要性不容小觑。它作为许多蛋白质的基本构建块，有助于其稳定性和功能。例如，许多转录因子——帮助调节基因表达的蛋白质——含有coiled coils，使它们能够二聚或聚合，从而增强它们结合DNA并促进转录的能力。这说明了蛋白质的结构特征如何直接影响其生物角色。此外，coiled coil结构不仅限于转录因子。它也出现在结构蛋白中，如角蛋白，这些蛋白质是头发、指甲和皮肤外层的重要组成部分。角蛋白中的coiled coil排列提供了必要的强度和韧性，使这些组织能够承受机械压力。因此，对coiled coils的研究不仅涉及简单的蛋白质相互作用；它涵盖了对生物体健康和发育至关重要的广泛生物功能。除了生物学的重要性，coiled coils在生物技术和材料科学领域也引起了兴趣。研究人员正在探索设计合成蛋白质的潜力，这些蛋白质包含coiled coil基元，用于各种应用，例如药物递送系统、生物材料和纳米技术。通过操纵coiled coils的特性，科学家希望创造出创新的解决方案，以应对医学和工程中的挑战。此外，对coiled coils的研究已导致我们对疾病理解的重大进展。涉及coiled coils的蛋白质折叠和相互作用异常与多种疾病相关，包括神经退行性疾病和癌症。理解这些结构正常功能的方式可以提供有关其功能失调如何导致疾病的见解，为新的治疗策略铺平道路。总之，coiled coil基元是大自然在蛋白质设计方面的非凡典范。它的多功能性和功能性使其成为分子生物学、生物技术和医学研究的重点。随着我们不断解开coiled coils的复杂性，我们对生命的分子基础有了更深入的认识，并为科学创新开辟了新途径。对coiled coils的探索不仅增强了我们对生物学的理解，而且为可能会革新医疗和技术的实际应用带来了希望。