aldolase

简明释义

英[ˈældəʊˌleɪz]美[ˈældəˌleɪs]

n. [生化] 醛缩酶；[生化] 二磷酸果糖酶

英英释义

单词用法

同义词

反义词

例句

1.Animal experiments demonstrated that uracil and uridine were capabie of lowering the elevated serum aldolase level of mice suffering from experimental myotonia.

动物实验证明，尿嘧啶和尿嘧啶核苷对实验性肌强直症小鼠血清醛缩酶有降低作用。

2.The reactions between aldolase and TNBS suggest that the amino group or groups, in snake aldolase, may play a special role in maintaining its native conformation.

醛缩酶和TNBS之间的反应支持酶分子的氨基，尤其是蛇肌醛缩酶的氨基在维护其天然构象中起着特殊作用的观点。

3.The reactions between aldolase and TNBS suggest that the amino group or groups, in snake aldolase, may play a special role in maintaining its native conformation.

醛缩酶和TNBS之间的反应支持酶分子的氨基，尤其是蛇肌醛缩酶的氨基在维护其天然构象中起着特殊作用的观点。

4.In male worms, only aldolase, mannose 6 phosphate isomerase and glucose 6 phosphate dehydrogenase were slightly inhibited.

在上述观察时间内，雄虫的醛缩酶、6 -磷酸甘露糖异构酶和6 -磷酸葡萄糖脱氢酶活性受一定的影响。

5.The results indicate that aldolase owns high conservation in its amino acid sequence.

醛缩酶氨基酸序列保守性较高。

6.In muscle tissues, aldolase helps convert carbohydrates into usable energy.

在肌肉组织中，aldolase帮助将碳水化合物转化为可用能量。

7.Researchers are studying the effects of aldolase on cancer cell metabolism.

研究人员正在研究aldolase对癌细胞代谢的影响。

8.The enzyme aldolase plays a crucial role in glycolysis, breaking down glucose into energy.

酶aldolase在糖酵解中起着关键作用，将葡萄糖分解为能量。

9.Deficiency of aldolase can lead to serious metabolic disorders.

缺乏aldolase可能导致严重的代谢紊乱。

10.The presence of aldolase in the blood can be a marker for certain diseases.

血液中存在aldolase可能是某些疾病的标志。

作文

Aldolase is an important enzyme that plays a crucial role in the glycolytic pathway, which is essential for cellular energy production. This enzyme catalyzes the reversible condensation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. The significance of aldolase (醛缩酶) lies in its ability to facilitate the breakdown of glucose, allowing cells to harness energy efficiently. Understanding how aldolase (醛缩酶) functions can provide insights into various metabolic disorders, including diabetes and cancer.In the human body, there are three isoforms of aldolase (醛缩酶): aldolase A, B, and C, each of which is expressed in different tissues. Aldolase A is primarily found in muscle tissue, while aldolase B is predominantly present in the liver. Aldolase C is mainly expressed in the brain. The distinct roles of these isoforms highlight the enzyme's adaptability in meeting the energy demands of various tissues.The regulation of aldolase (醛缩酶) activity is tightly controlled by various factors, including substrate availability and allosteric effectors. For instance, high levels of fructose-1,6-bisphosphate can enhance the activity of aldolase (醛缩酶), promoting glycolysis when energy is needed. Conversely, when energy levels are sufficient, the activity of aldolase (醛缩酶) may be downregulated to prevent excessive energy production.Research has shown that abnormalities in aldolase (醛缩酶) activity can lead to various health issues. For example, a deficiency in aldolase A can result in muscle weakness and exercise intolerance, a condition known as aldolase A deficiency. Similarly, alterations in aldolase B activity have been linked to hereditary fructose intolerance, a genetic disorder that affects the metabolism of fructose. These examples illustrate the importance of aldolase (醛缩酶) in maintaining metabolic homeostasis.Moreover, recent studies have explored the potential role of aldolase (醛缩酶) in cancer metabolism. Cancer cells often exhibit altered energy metabolism, known as the Warburg effect, where they rely on glycolysis even in the presence of oxygen. This shift allows cancer cells to rapidly generate ATP and produce intermediates for biosynthesis. Targeting aldolase (醛缩酶) could provide a novel therapeutic strategy to disrupt the energy supply of tumor cells, offering new avenues for cancer treatment.In conclusion, aldolase (醛缩酶) is a vital enzyme involved in the glycolytic pathway, facilitating energy production in cells. Its various isoforms, regulatory mechanisms, and implications in health and disease underscore its significance in biochemistry and medicine. Continued research on aldolase (醛缩酶) will undoubtedly contribute to our understanding of metabolic processes and the development of targeted therapies for metabolic disorders and cancer.