fischer's indole synthesis

简明释义

费希尔吲哚合成

英英释义

例句

1.The versatility of fischer's indole synthesis 费舍尔吲哚合成 allows chemists to create various functionalized indoles.

由于费舍尔吲哚合成的多功能性，化学家能够合成各种功能化的吲哚。

2.Many pharmaceutical companies utilize fischer's indole synthesis 费舍尔吲哚合成 to develop new drug candidates.

许多制药公司利用费舍尔吲哚合成开发新的药物候选者。

3.When teaching about heterocyclic compounds, I always highlight fischer's indole synthesis 费舍尔吲哚合成 as a key reaction.

在讲授杂环化合物时，我总是强调费舍尔吲哚合成作为一个关键反应。

4.In organic chemistry, we often discuss fischer's indole synthesis 费舍尔吲哚合成 as a crucial method for creating indole derivatives.

在有机化学中，我们经常讨论费舍尔吲哚合成作为合成吲哚衍生物的重要方法。

5.The reaction mechanism of fischer's indole synthesis 费舍尔吲哚合成 involves the formation of a cyclic intermediate.

费舍尔吲哚合成的反应机制涉及环状中间体的形成。

作文

The world of organic chemistry is filled with fascinating reactions and syntheses that have paved the way for numerous discoveries and advancements in science. One such reaction that has garnered significant attention is the Fischer's indole synthesis. This reaction, developed by the German chemist Emil Fischer in the late 19th century, allows for the formation of indole derivatives from phenylhydrazine and a carbonyl compound. Understanding the mechanisms and applications of Fischer's indole synthesis can deepen our appreciation for its role in the development of pharmaceuticals, agrochemicals, and other important compounds.To grasp the significance of Fischer's indole synthesis, it is essential to explore its mechanism. The reaction begins with the condensation of phenylhydrazine with a carbonyl compound, typically an aldehyde or a ketone, to form an intermediate hydrazone. This intermediate then undergoes cyclization through a series of steps, ultimately resulting in the formation of indole. The versatility of this synthesis lies in its ability to produce various substituted indoles, which are valuable building blocks in the synthesis of more complex molecules.Indoles themselves are an important class of compounds in medicinal chemistry. They serve as key structural motifs in many natural products and synthetic drugs. For instance, the well-known antidepressant drug, fluoxetine, contains an indole structure. The ability to synthesize indoles efficiently through Fischer's indole synthesis has made it a crucial method in drug discovery and development. Researchers continue to explore new variations and modifications of this synthesis to enhance its efficiency and selectivity.Moreover, the impact of Fischer's indole synthesis extends beyond pharmaceuticals. Indole derivatives are also found in agrochemicals, dyes, and materials science. Their unique properties, such as fluorescence and photostability, make them suitable for a wide range of applications. As scientists strive to develop new materials and chemicals, the foundational knowledge provided by Fischer's indole synthesis remains invaluable.In conclusion, Fischer's indole synthesis is a remarkable example of how a single chemical reaction can have far-reaching implications across various fields. Its historical significance, coupled with its ongoing relevance in modern chemistry, highlights the importance of understanding such fundamental reactions. As we continue to unravel the complexities of organic synthesis, the contributions of pioneers like Emil Fischer remind us of the beauty and intricacy of chemical transformations. Through further research and innovation, the legacy of Fischer's indole synthesis will undoubtedly continue to inspire future generations of chemists and researchers.

有机化学的世界充满了迷人的反应和合成，这些反应和合成为许多发现和科学进步铺平了道路。其中一个引起广泛关注的反应是费舍尔吲哚合成。这一反应由德国化学家埃米尔·费舍尔在19世纪末开发，允许通过苯肼和碳基化合物形成吲哚衍生物。理解费舍尔吲哚合成的机制和应用可以加深我们对其在制药、农用化学品和其他重要化合物开发中作用的欣赏。为了掌握费舍尔吲哚合成的重要性，有必要探讨其机制。该反应开始于苯肼与碳基化合物（通常是醛或酮）的缩合，形成中间体肼酮。该中间体随后通过一系列步骤发生环化，最终形成吲哚。这种合成的多样性在于它能够生成各种取代的吲哚，这些吲哚是合成更复杂分子的宝贵构建块。吲哚本身是医药化学中重要的一类化合物。它们作为许多天然产物和合成药物的关键结构基元。例如，著名的抗抑郁药氟西汀就含有吲哚结构。通过费舍尔吲哚合成高效合成吲哚的能力，使其成为药物发现和开发中的关键方法。研究人员继续探索这种合成的新变体和修改，以提高其效率和选择性。此外，费舍尔吲哚合成的影响超出了制药领域。吲哚衍生物也出现在农用化学品、染料和材料科学中。它们独特的性质，例如荧光和光稳定性，使它们适用于广泛的应用。随着科学家努力开发新材料和化学品，费舍尔吲哚合成提供的基础知识仍然是无价的。总之，费舍尔吲哚合成是一个非凡的例子，说明了单一化学反应如何在各个领域产生深远影响。其历史重要性，加上在现代化学中的持续相关性，突显了理解这些基本反应的重要性。随着我们继续揭示有机合成的复杂性，像埃米尔·费舍尔这样的先驱的贡献提醒我们化学转化的美丽和复杂性。通过进一步的研究和创新，费舍尔吲哚合成的遗产无疑将继续激励未来一代化学家和研究人员。